Agenda

Day 1
29 Sep 2022

Poster Set-Up

Posters should be on display from Thursday morning through Saturday evening so they are available for viewing both at the designated time with the authors and informally (without authors) at coffee breaks and lunch.

Welcome / Patient Story

A warm welcome from the Organizing Committee Co-Chair and an encouraging patient story.

Session 1: Keynote Speaker

Preclinical Models of HHT Disease: Mechanisms, Therapies and Controversies
Helen Arthur, PhD
9:25 am - 9:40 am

Break

Session 2: Bleeding, Thrombosis, Anemia and Iron in HHT

Invited Speaker:  Dr. Michael Auerbach  (9:40am – 10:25am) Utilization, Safety and Efficacy of Intravenous Iron   Oral Presentations (10:25am – 11:50am)    
Michael Auerbach, MD, FACP

Session 3: Medical Therapeutics I: Novel Agents

Invited Speaker:  Nicholas Benedict  (11:50am – 12:20pm) Building a Company with a Novel Therapeutic for HHT    
Nicholas Benedict
12:30 pm-1:15 pm

Lunch

Session 3: Medical Therapeutics I: Novel Agents

Invited Speaker: Captain Robyn Bent (virtual) (1:15pm-1:45pm) Patient Focused Drug Development and the Rare Diseases Cures Accelerator   Oral Presentations (1:45pm-2:35pm)  
Capt. Robyn Bent, RN, MS
2:35 pm-2:45 pm

Break

Session 4: Cell Signaling and other Vascular Anomalies

Invited Speaker:  Dr. Mariona Graupera (2:45pm-3:15pm) Insights in PIK3CA and Vascular Malformations   Invited Speaker: Dr. Marlene Rabinovitch (virtual) (3:15pm – 3:45pm) Loss of BMPR2 and Impaired Endothelial Homeostasis   Oral Presentations (3:45pm – 5:00pm)    
Mariona Graupera, PhD
Marlene Rabinovitch, MD

Research Poster Blitz

Highlight of 7 posters for the evening
5:15 pm - 8:00 pm

Dinner Break

Research Poster Session

Wine and Cheese Poster Session  
Day 2
30 Sep 2022

Welcome / Patient Story

A warm welcome from the Organizing Committee Co-Chair and an encouraging patient story.

Session 5: Diagnostic and Clinical Imaging in HHT

Invited Speaker:  Dr. Mickael Tanter  (8:15am – 9:00am) Ultrasound Imaging for Cerebral Small Vessel Disease and Neuroimaging   Oral Presentations (9:00am – 10:15am)    
Mickael Tanter, PhD
10:15 am – 10:30 am

Break

Session 6: Molecular and Cellular Mechanisms

Invited Speaker:  Dr. Kristina Bostrom (10:30am – 11:15am) Mechanism of Matrix Gla Protein in Vascular Formation and Disease   Oral Presentations (11:15am – 12:15pm)
Kristina Bostrom, MD, PhD

Research Poster Blitz

Highlight of 7 posters for the afternoon

Lunch and Poster Session

Poster Session (#even numbers)

Cure HHT Research Network Workstream Reports

Overview of eight priority research areas identified by the patient, clinician and science communities.
2:50 pm– 3:00 pm

Break

Session 7: Medical Therapeutics II: Repurposed Agents

Invited Speaker: Dr. Roger Lewis (virtual) (3:00pm – 3:45pm) Adaptive and Platform Trial Design for the Efficient Evaluation of Treatments for HHT   Oral Presentations (3:45pm – 4:45pm)  
Roger Lewis, MD, PhD
Day 3
01 Oct 2022

Welcome / Patient Story

A warm welcome from the Organizing Committee Co-Chair and an encouraging patient story.

Session 8: Hemodynamics and Cell Biology

Invited Speaker: Dr. Claudio A. Franco (8:15am – 9:00am) Novel Insights on AVM Formation from a Non-Genetic Mouse Model   Oral Presentations (9:00am – 10:00am)  
Claudio A. Franco, PhD

Session 9: Workshop Session B

Current and future therapies for HHT: Mechanistic and clinical considerations

Session 9: Workshop Session A

AVM formation and progression: Mechanistic and clinical considerations

Proceedings of the International Expert Case Conference (2021-2022)

Speakers: Dr. Miles Conrad and Dr. Els de Gussem
Els Maria de Gussem, MD
Miles Conrad, MD, MPH

Session 9: Workshop Session C (Optional)

Invited Speakers: Dr. Andrei Kindzelski and Mark Vieth Funding Opportunities at the NIH and DOD  
Mark Vieth
Andrei Kindzelski, MD, PhD
12:30 pm-1:30 pm

Lunch

Session 10: Diagnostics in HHT

Invited Speaker: Dr. William Sellers (1:30pm – 2:15pm) The Elements of Successful Drug Discovery   Oral Presentations (2:15pm – 3:15pm)      
William Sellers, MD
3:15 pm – 3:30 pm

Break

Session 11: Genetics and Gene Therapy in HHT

Invited Speaker: Dr. David Liu (virtual) (3:30pm – 4:15pm) Base Editing and Prime Editing: Precise Gene Correction Without Double-Strand DNA Breaks   Oral Presentations  (4:15pm – 5:15pm)    
David R. Liu, PhD
5:15 pm-7:00 pm

Break

Day 4
02 Oct 2022

Welcome / Patient Story

A warm welcome from the Organizing Committee Co-Chair and an encouraging patient story.

Session 12: Procedural and Surgical Treatment

Invited Speaker: Dr. Hans-Jurgen Mager (8:15am – 8:45am) Management of Pulmonary AVMs   Invited Speaker: Dr. Waleed Brinjikji (8:45am – 9:15am)   Oral Presentations (9:15am – 10:30am)  
Hans-Jurgen Mager, MD, PhD
10:30 am-10:45 am

Break

Session 13: Epidemiology

Invited Speaker: Dr. Douglas Marchuk (10:45am – 11:15am) Somatic Mutations Initiate and Drive the Growth of Vascular Malformations   Oral Presentations (11:15am – 12:30pm)  
Douglas Marchuk, PhD
12:30 pm-12:45 pm

Break

Conference Summary / Awards

Basic Science Summary;  Clinical Science Summary;  Presentation Awards
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