Session 12: Mechanism of HHT    

11 Jun 2017
8:00 am – 9:45 am
Soderini Ballroom II, III

Session 12: Mechanism of HHT    

Invited Speaker:  Dr. Arndt Siekmann  (8:00am – 8:45am)

Endoglin Controls Blood Vessel Diameter Through Endothelial Cell Shape Changes

 

Oral Presentations 

8:45am – 9:00am

Isogenic induced pluripotent stem cells (IPSCS) derived from mosaic hereditary hemorrhagic telangiectasia type 1 (HHT1) patient

Orlova V, Cao X, Freund C, Sánchez-Duffhues G, Hawinkels L, Petrus-Reurer S, van den Hil FE, Disch F, Snijder RJ, Westermann CJJ, Mager JJ, ten Dijke P, Ploos van Amstel JK, Mummery CL

 

9:00am – 9:15am

Telangiectasia-on-a-chip: an in vitro model of hereditary hemorrhagic telangiectasia incorporating perfused vessels

Andrejecsk JW, Hughes CCW

 

9:15am – 9:30am

Somatic ALK1 gene mutations mediated by an adenoviral vector expressing CRISPR/CAS9 induces arteriovenous malformation in the brain angiogenic region of adult mice

Zhu W, Su H

 

9:30am – 9:45am

A novel SMAD4 mouse model of HHT

Crist A, Meadows S