Posters should be on display from Thursday morning through Friday evening, but it is recommended that all posters remain on display through Sunday so they are available for viewing both at the designated time with the authors and informally (without authors) at coffee breaks and lunch.
Invited Speaker: Dr. Anne Eichmann (8:30am – 9:15am) Vascular Mispatterning in HHT Disease Oral Presentations 9:15am – 9:30am Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification Jakobsson L, Jin Y, Muhl L, Burmakin M, Wang Y, Duchez AC, Betsholtz C, Arthur H 9:30am – 9:45am Arterial-venous malformation form through canonical SMAD4 Signaling Ola R, Eichmann A 9:45am – 10:00am Identification of TGF-Beta downstream effectors: a SMAD4 directed approach reveals a link between angiopoietin signaling and HHT Meadows S, Crist A 10:00am – 10:15am Cardiosphere derived cells require endoglin to promote paracrine-mediated angiogenesis. Arthur... Read More
Invited Speaker: Dr. Luca Jovine (10:30am – 11:15am) What the Human Endoglin-BMP9 Complex Looks Like and What Does It Tell Us Oral Presentations 11:15am – 11:30am Effect of systemic bevacizumab on invasive cardiac hemodynamics among patients with hereditary hemorrhagic telangiectasia and high output heart failure. Allred C, Johnson K, Whitehead K 11:30am – 11:45am Intravenous bevacizumab for the management of transfusion dependent blood-loss anemia in hereditary hemorrhagic telangiectasia A standardized treatment protocol of Intravenous Bevacizumab for refractory HHT related epistaxis and gastrointestinal bleeding Iyer V, Apala D, Pannu B, Kotecha A, Brinjikji W, Leise M, Kamath P, Misra S,... Read More
Invited Speaker: Dr. Rosemary Akhurst (1:45pm – 2:30pm) Genetic Variants Modify TGFb/BMP Signaling and Clinical HHT Phenotypes Oral Presentations 2:30pm – 2:45pm Clinical, radiographic, and genetic findings of a cohort of 39 patients with hereditary hemorrhagic telangiectasia and brain vascular malformations Kalani MYS, Joyce E, Eli I, Park, M, Taussky P, Schmidt R, McDonald J, Whitehead K 2:45pm – 3:00pm Comparison of MRI and digital subtraction angiography for detection of cerebral arteriovenous malformations in hereditary hemorrhagic telangiectasia Hetts S, Vella M, Alexander M, Mabray M, Dickey M 3:00pm – 3:15pm Vitamin D levels are associated with decreased... Read More
You have the option of purchasing an afternoon leisure activity with the other conference attendees. This is a separate fee from conference registration. The shuttle boat will depart for the group from the hotel’s marina at 03:30 pm. Boat Ride – 45 minute boat ride to Old Town Dubrovnik. Enjoy a leisure afternoon exploring old city centre on your own and take a shuttle bus back to the resort. Shuttle boat 11,00€ (per person, each way); Shuttle bus 6,00€ (per person, each way). Guided Tour by Boat & Cable Car – The 2 hour tour starts with a boat ride to... Read More
Invited Speaker: Dr. Aravind Asokan (8:00am – 8:45am) Towards a Gene Therapy Approach for Vascular Disorders Oral Presentations 8:45am – 9:00am Evaluation of stop codon read through as a therapy for HHT Aldred M, Sadler T, Shovlin C 9:00am – 9:15am Mice lacking endoglin in macrophages show an impaired immune response. Botella L, Arthur H, Bernabeu C, Ojeda-Fernández L 9:15am – 9:30am Mosaicism involving non-blood tissue: implications for genetic testing in HHT families McDonald J, Wooderchak-Donahue W, Paul E, Morris A, Bayrak-Toydemir P 9:30am – 9:45am Endoglin antibody therapy produces the small vessel manifestations of HHT-1... Read More
Oral Presentations 10:05am – 10:20am VASCERN HHT priority evaluations 2016-2017 (European Reference Network on Rare Multisystemic Vascular Diseases) Shovlin CL, Botella L, Geisthoff U, Kjeldsen A, Mage JJ, Pagella F, Sabbà C, Buscarini E, Dupuis Girod S on behalf of the VASCERN-HHT Working Group 10:20am – 10:35am Narratives describing the impact of living with HHT: a qualitative study Bogwitz M, Taylor J, Sexton A, Gargan B, Winship I 10:35am – 10:50am Assessment of an age-related threshold of nasal, oral and cutaneous telangiectasia number for diagnosis of hereditary hemorrhagic telangiectasia: HHT Paris Center experience in 832 genotyped HHT patients. El... Read More
Invited Speaker: Dr. Philippe Marambaud (1:30pm – 2:15pm) Therapeutic Potential of ALK1 Activating Drugs in HHT Models Oral Presentations 2:15pm – 2:30pm Decreased expression of VEGFR1 contributes to the pathogenesis of Hereditary Hemorrhagic Telangiectasia type 2 Lebrin F, Thalgott J, Dos-Santos-Luis D, Hosman AE, Martin S, Bracquart D, Srun S, Lamandé N, Carette MF, Oh SP, Westermann CJ, Snijder RJ, Mager JJ, Mummery CL, Rabelink TJ, Raymond K 2:30pm – 2:45pm Nitric oxide synthase inhibition attenuates Notch-mediated brain arteriovenous malformation Wang R, Huang L 2:45pm – 3:00pm Overexpression of alk1 in endothelial cells suppresses development of arteriovenous... Read More
Oral Presentations (3:35pm – 4:35pm) 3:35pm – 3:50pm Clinical Analysis of 200 Japanese HHT patients Komiyama M, Terada A, Ishiguro T, Morisaki H, Miyatake S, Matsumoto N 3:50pm – 4:05pm Hereditary hemorrhagic telangiectasia (HHT)—a retrospective study of ten patients Ivic M, Radic B, Kusec R, Pejsa V, Grgurevic I, Mitrovic Z 4:05pm – 4:20pm The relevance of HHT Europe (Federation of Patient Organizations) in improving patients centered activities and patient involvement in outcomes for HHT Crocione C, Grabowski C, Muñoz B, Topaz Druckman K (Patient Advocates) 4:20pm – 4:35pm HHT—a South African perspective on diagnosis, management and... Read More
Oral Presentations 3:35pm – 3:50pm Are there any further HHT genes to be discovered?—an exome sequences study Tørring PM, Brusgaard K, Kjeldsen AD, Pinheiro R, Ousager LB 3:50pm – 4:05pm Variants in endoglin and non-HHT phenotypes Brilliant M, Hoch B, Ye Z, Mayer J, Hebbring S 4:05pm – 4:20pm Next generation sequencing in HHT genetic diagnosis Giraud S, Auboiroux C, Chambe, Dupuis-Girod S, Riviere S, Harle JR, Gerard M, Astudillo L, Mohamed S, Lesca G, Calender A 4:20pm – 4:35pm Two interesting cases of molecular diagnosis for HHT: low-level mosaicism and abnormal splicing of ACVRL1 Trevors C,... Read More
7:00pm – 7:30pm Cocktails 7:30pm – 11:00pm Dinner and Dancing Let’s celebrate the discoveries, collaborations, friendships, and new opportunities with a traditional Croatian dinner All conference attendees and their registered adult guests are invited to attend. A DJ will provide popular music from all genres. Plan to dance the night away!
Oral Presentations 10:05am – 10:20am Long-term outcomes for radiosurgical management of brain arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia Surgical treatment versus non-surgical treatment for brain arteriovenous malformations in patients with hereditary hemorrhagic telangiectasia: a retrospective multicenter consortium study Tayebi Meybodi A, Kim H, Nelson J, Hetts S, Krings T, ter Brugge K, Faughnan M, Lawton M, and the Brain Vascular Malformation Consortium HHT Investigator Group 10:20am – 10:35am Systemic to pulmonary arteriovenous malformations (SPAVM): a distinct entity from HHT PAVMS clinically, on imaging, and for embolization, with whole genome analysis Mitchell S, Terry P, Ringel R, Sobreira... Read More