Posters should be on display from Thursday morning through Friday evening, but it is recommended that all posters remain on display through Sunday so they are available for viewing both at the designated time with the authors (see below) and informally (without authors) at coffee breaks and lunch.
Invited Speaker (1:30pm – 2:15pm) Therapeutic potential of ALK1 activating drugs in HHT models Hereditary hemorrhagic telangiectasia (HHT) is a vascular disorder arising from aberrant endothelial cell-driven hypervascularization, and caused by loss-of-function mutations in the BMP9-ALK1-Smad1/5/8 signaling pathway. Interventions that would activate ALK1 signaling might therefore have therapeutic potential in HHT. By screening the NIH clinical collections of FDA-approved drugs, we have recently identified several molecules capable of activating ALK1 signaling in BMP9-challenged C2C12 reporter cells. In human primary endothelial cells (HUVECs), the most potent drug identified, tacrolimus (FK506), activated Smad1/5/8 and opposed the pro-angiogenic transcriptional response of ALK1 loss-of-function... Read More